Can antidepressant mono therapy in cyclothymic disorder cause full blown mania? Is that a sure sign of type 1 bipolar disorder?

Let’s start with a little diagnostic jargon. Officially, we use the term cyclothymic disorder to describe a mood pattern including both mild depression and hypomania—with neither severe enough to make a diagnosis of bipolar disorder. And we use the term bipolar disorder type 2 to refer to a mood pattern including both major depression and hypomania. Finally, we use the term bipolar disorder type 1 to refer to a mood pattern including both major depression and full mania. Full mania means that significant manic symptoms last at least 7 days or lead to hospitalization.

Antidepressant medications can certainly cause mania, especially if they are used alone (without a mood stabilizer or anti-manic medication). That can happen in people with no history of hypomania or mania—but this risk is higher in people with type 2 bipolar disorder and highest in people with type 1 bipolar disorder. In other words, a history of mania increases the odds that taking an antidepressant can bring on mania.

Officially, a manic episode brought on by taking an antidepressant would not add up to a diagnosis of bipolar disorder. But it would certainly identify someone at higher risk for having a manic episode in the future, with or without antidepressant medication. My advice to anyone who experienced mania after starting an antidepressant would be: You should make sure any doctor who wants to prescribe an antidepressant knows about this! Some people have used the term “type 3 bipolar disorder” for the pattern of depression with a manic episode that ONLY happened while taking antidepressants. But psychiatrists do like to name things!

About the Doc

About the Doc

Greg Simon, MD, MPH, is a psychiatrist at Washington Permanente Medical Group and senior investigator at Kaiser Permanente Washington Health Research Institute well-known for his extensive research on practical approaches to improving mental health care. He seeks to develop and evaluate effective real-world strategies that support better mental health and wellness.  Current areas of emphasis include identifying and assessing suicide risk, improving care for treatment-resistant depression, and reducing racial and ethnic disparities in mental health care.